头颈部放射性脊髓炎 参麦注射液在头颈部肿瘤放疗中减轻放射性不良反应的临床调查

陈飞　余婷婷　刘晓安

[摘要] 意图 调查参麦注射液在头颈部肿瘤放疗中减轻放射性不良反应的临床作用。 办法 剖析2015年3月～2017年3月我院收治的128例头颈部肿瘤放疗患者的临床材料，核算总有功率；总的放疗2～4级急性损害发作率、中重度痛苦发作率、日子质量下降发作率；放疗完结1个月后的日子质量改进发作率。 成果 调查组患者医治的总有功率[93.75%（60/64）]显着高于对照组[81.25%（52/64）]，差异具有统计学含义（P<0.05）；总的放疗2～4级急性损害发作率显着低于对照组，差异具有统计学含义（P<0.05），中重度痛苦发作率31.25%（20/64）显着低于对照组的68.75%（44/64），差异具有统计学含义（P<0.05）；放疗完结1个月后调查组患者的日子质量改进发作率93.75%（60/64），显着高于对照组62.50%（40/64），差异具有统计学含义（P<0.05），调查组患者日子质量下降发作率0%（0/64），显着低于对照组的15.63%（10/64），差异具有统计学含义（P<0.05）。 定论 参麦注射液在头颈部肿瘤放疗中减轻放射性不良反应的临床作用显著。

[关键词] 参麦注射液；头颈部肿瘤放疗；临床作用；放射性不良反应

[中图分类号] R273 [文献标识码] B [文章编号] 1673-9701（2017）28-0095-03

[Abstract] Objective To observe the clinical effect of Shenmai injection on reducing radioactive adverse reactions in head and neck tumor radiotherapy. Methods The clinical data of 128 patients with head and neck tumor radiotherapy who were admitted to our hospital from March 2015 to March 2017 were statistically analyzed. The total effective rate was calculated； total incidence rate of grade 2-4 acute injury by radiotherapy； incidence rate of moderate to severe pain； incidence rate of quality of life reduction； incidence rate of improvement in quality of life after one month of radiotherapy were compared. Results The total effective rate was 93.75%（60/64） in the observation group， which was significantly higher than that of 81.25%（52/64） in the control group，the difference was significant（P<0.05）； the total incidence rate of grade 2-4 acute injury was significantly lower than that in the control group，the difference was significant（P<0.05）. The incidence rate of moderate to severe pain was 31.25%（20/64）， which was significantly lower than that of 68.75%（44/64） in the control group， the difference was significant（P<0.05）； the improvement rate of quality of life in the observation group was 93.75%（60/64）， the difference was significant， which was significantly higher than that of 62.50%（40/64） in the control group， the difference was significant（P<0.05）. The incidence rate of life quality reduction was 0%（0/64） in the observation group， which was significantly lower than that of 15.63%（10/64） in the control group， the difference was significant（P<0.05）. Conclusion Shenmai injection in the head and neck tumor radiotherapy has a significant clinical effect of reducing radioactive adverse effects.

[Key words] Shenmai injection； Head and neck tumor radiotherapy； Clinical efficacy； Radioactive adverse reactions

放射治療为头颈部恶性肿瘤重要的医治手法，尽管放疗的设备和技能有了长足的前进，如适形、调强、立体定向放疗，但无法防止放疗的毒副反应及并发症的发作，因而放疗过程中呈现的不良反应常使患者中止医治，使作用下降，病程延伸，患者生计质量严峻下降。祖国医学以为放射线是炽热阳毒之邪，可伤阴耗气，灼伤津液，而参麦注射液归于纯中药抗癌药物，首要成效为清热解毒、镇痛等[1]。本研讨对2015年3月～2017年3月我院收治的128例头颈部肿瘤放疗患者的临床材料进行统计剖析，调查参麦注射液在头颈部肿瘤放疗中减轻放射性不良反应的临床作用，现报导如下。endprint